Combinations ; Lisinopril/Hydrochlorthiazide see below;
Dosage ; Hypertension: 2.5mg daily.
Maintenance dose: 10-20mg daily (max. 40mg daily).
Adjunct in heart failure treatment: 2.5mg daily. Maintenance: 5-20mg daily.
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Auroliza | Aurobindo Pharma Ltd. | Simba Pharmaceutical Ltd. | 5mg | 28 | Tablet | per tablet | KES 120.00 |
| Auroliza | Aurobindo Pharma Ltd. | Simba Pharmaceutical Ltd. | 10mg | 28 | Tablet | per tablet | KES 250 |
| Lisace | Cosmos Limited. | Cosmos Limited | 5mg | 28 | Tablet | per tablet | KES 180.00 |
| Lisace | Cosmos Limited. | Cosmos Limited | 10mg | 28 | Tablet | per tablet | KES 300.00 |
| Lisinopril | Arrow Generics | Metro Pharmaceuticals Ltd. | 5mg | 28 | Tablet | per tablet | KES 144.00 |
| Lisinopril | Arrow Generics | Metro Pharmaceuticals Ltd. | 10mg | 28 | Tablet | per tablet | KES 200.00 |
| Listril | Torrent Pharmaceuticals Ltd. | Medox Pharmaceuticals Ltd. | 5mg | 100 | Tablet | per tablet | KES 1,270 |
| Listril | Torrent Pharmaceuticals Ltd. | Medox Pharmaceuticals Ltd. | 10mg | 100 | Tablet | per tablet | KES 2,200 |
| Zestril | AstraZeneca | Radiance Pharmaceuticals Limited | 5mg | 28 | Tablet | per tablet | KES 1,034.00 |
| Zestril | AstraZeneca | Radiance Pharmaceuticals Limited | 5mg | 700 | Tablet | per tablet | KES 46,809 |
| Zestril | AstraZeneca | Radiance Pharmaceuticals Limited | 10mg | 28 | Tablet | per tablet | KES 2,091 |
| Zestril | AstraZeneca | Radiance Pharmaceuticals Limited | 20mg | 700 | Tablet | per tablet | KES 46,809 |
| Zestril | AstraZeneca | Radiance Pharmaceuticals Limited | 20mg | 28 | Tablet | per tablet | KES 2,460.00 |
| Zestril | AstraZeneca | Radiance Pharmaceuticals Limited | 20mg | 700 | Tablet | per tablet | KES 46,809.00 |
| Zestril | AstraZeneca | Radiance Pharmaceuticals Limited | 10mg | 700 | Tablet | per tablet | KES 37,391.00 |
| Lisinopril More info | |
|---|---|
| Mode Of Action | Inhibition of the conversion of angiotensin I to angiotensin II. |
| Drug Indication | Hypertension, Congestive heart failure. |
| Precautions | Severe CCF, impaired renal function, lactation, aortic stenosis, NSAIDs, monitor serum lithium levels, first dose may cause hypotension especially in dehydrated cases, low sodium serum levels, diuretic treated cases, monitor renal function, may potentiate hypoglyceamic effects of insulin or oral hypoglycaemic agents, haematological monitoring. Avoid potassium sparing diuretics or potassium supplements. |
| Contra-Indications | Pregnancy, history of angioneurotic oedema with previous ACE inhibitors, hypersensitivity, renal vascular disease, porphyria. |
| Side Effects | Persistent dry cough, voice changes, chest pain, taste disturbances, bronchospasm, blood dyscrasias, tachycardia, increased serum potassium levels, anaphylactic reactions, hepatic /renal impairment, hypotension, GI disturbances, muscle cramps, sleep disturbances, flushing, asthenia, impotence, CVS disorders. |
| Dosage | Hypertension: 2.5mg daily. Maintenance dose: 10-20mg daily (max. 40mg daily). Adjunct in heart failure treatment: 2.5mg daily. Maintenance: 5-20mg daily. |
| Pregnancy Category | Category D |
| Pregnancy Category Description | Drugs, which have caused, are suspected to have caused, or may be expected to cause an increased rise in the frequency of malformations or irreversible damage. These drugs may also have adverse pharmacological effects required required |
| Drug Category | DRUGS ACTI NG ON THE CARDIO-VASCULAR SYSTEM |
| Drug Sub-Category | Angiotensin-converting enzyme inhibitors |
| Lisinopril/Hydrochlorthiazide More info | |
|---|---|
| Mode Of Action | Inhibition of the conversion of angiotensin I to angiotensin II and diuresis |
| Drug Indication | Hypertension, Congestive heart failure. |
| Precautions | Severe CCF, impaired renal function, lactation, aortic stenosis, NSAIDs, monitor serum lithium levels, first dose may cause hypotension especially in dehydrated cases, low sodium serum levels, diuretic treated cases, monitor renal function, may potentiate hypoglyceamic effects of insulin or oral hypoglycaemic agents, haematological monitoring. Avoid potassium sparing diuretics or potassium supplements. |
| Contra-Indications | Pregnancy, history of angioneurotic oedema with previous ACE inhibitors, hypersensitivity, renal vascular disease, porphyria. |
| Side Effects | Persistent dry cough, voice changes, chest pain, taste disturbances, bronchospasm, blood dyscrasias, tachycardia, increased serum potassium levels, anaphylactic reactions, hepatic /renal impairment, hypotension, GI disturbances, muscle cramps, sleep disturbances, flushing, asthenia, impotence, CVS disorders. |
| Dosage | ACE inhibitor / thiazide diuretic to be used in-patients stabilized on the individual components in the same proportions |
| Pregnancy Category | Category D |
| Pregnancy Category Description | Drugs, which have caused, are suspected to have caused, or may be expected to cause an increased rise in the frequency of malformations or irreversible damage. These drugs may also have adverse pharmacological effects required required |
| Drug Category | DRUGS ACTI NG ON THE CARDIO-VASCULAR SYSTEM |
| Drug Sub-Category | Angiotensin-converting enzyme inhibitors |